Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation | Zendy

PHILP DEBORAH | Zendy; STSURIN SHARLEEN | Zendy; CHA HEEJAE | Zendy; MOON HYESUNG | Zendy; KLEINMAN HYNDA K. | Zendy; ELKIN MICHAEL | Zendy

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Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation

Author(s) -

PHILP DEBORAH,

STSURIN SHARLEEN,

CHA HEEJAE,

MOON HYESUNG,

KLEINMAN HYNDA K.,

ELKIN MICHAEL

Publication year - 2007

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1415.009

Subject(s) - thymosin , hair follicle , microbiology and biotechnology , angiogenesis , wound healing , beta (programming language) , chemistry , protease , cell growth , cell migration , stem cell , hair growth , cell , biology , immunology , biochemistry , cancer research , enzyme , physiology , computer science , programming language

: Thymosin beta 4 is a small 43‐amino‐acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production .

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