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In Vivo Sampling of Extracellular β‐Thymosin by Ultrafiltration Probes
Author(s) -
LIU YUTSUENG,
HUANG CHUNMING
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1415.001
Subject(s) - thymosin , extracellular , in vivo , ultrafiltration (renal) , chemistry , extracellular matrix , microbiology and biotechnology , biophysics , biochemistry , biology
: In vivo detection and monitoring of extracellular β‐thymosin will facilitate the understanding of their biological function and association with disease progression. A novel technique using capillary ultrafiltration (CUF) probes linked to mass spectrometry is capable of sensing extracellular thymosin β‐4 and/or thymosin β‐10 in vivo in wounded skin and other tissue microenvironments. In this review, we highlight the association of extracellular β‐thymosin with skin wound healing and the potential adjuvant effects on vaccination. The fabrication and biological application of CUF probes are also described. Data from CUF probe‐captured β‐thymosin may guide future exploration of extracellular β‐thymosin .