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Mesothelioma and Environmental Exposure
Author(s) -
Varga Csaba,
Szendi Katalin
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1414.012
Subject(s) - mesothelioma , chrysotile , mesothelial cell , peritoneal mesothelioma , asbestos , mesothelium , pathology , medicine , chemistry , cancer research , materials science , metallurgy
A novel animal model was developed to study the direct exposure of mesothelial cells to crocidolite and chrysotile asbestos fibers. Chemically pure and pretreated Union Internationale Centre le Cancer (UICC) samples were implanted into a peritoneal envelope (Kertai's fold) of Wistar rats. Following the 12‐month exposure, lack of mesothelioma induction was detected in all groups. Results suggest that the mechanism of mesothelioma formation is not a consequence of peritoneal physical exposure to the fibers.