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Lymphatics in Lung Disease
Author(s) -
ElChemaly Souheil,
Levine Stewart J.,
Moss Joel
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1413.017
Subject(s) - lymphatic system , lymphangiogenesis , lung , lung cancer , pathogenesis , disease , pathology , lung disease , medicine , respiratory disease , immunology , biology , cancer , metastasis
The lymphatic circulation appears to be a vital component in lung biology in health and in disease. Animal models have established the role of the lymphatic circulation in neoplastic and inflammatory diseases of the lung, such as asthma and cancer, and allowed for the understanding of the molecular controls of lymphangiogenesis in normal lung development. Understanding the role of lymphatics in human lung disease appears likely to contribute to the understanding of the pathogenesis of disease and the development of novel therapeutic targets.