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The Clinical Spectrum of Lymphatic Disease
Author(s) -
Radhakrishnan Kavita,
Rockson Stanley G.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1413.015
Subject(s) - lymphatic system , lymphedema , lymphangioleiomyomatosis , disease , lymphangioma , enteropathy , lymphangiectasia , medicine , pathology , lymphatic disease , lymphangiogenesis , lymphangiomatosis , tuberous sclerosis , cancer , breast cancer , metastasis
Lymphatic disease is quite prevalent, and often not well clinically characterized. Beyond lymphedema, there is a broad array of human disease that directly or indirectly alters lymphatic structure and function. The symptomatic and objective presentation of these patients can be quite diverse. In this review, we have attempted to provide a systematic overview of the subjective and objective spectrum of lymphatic disease, with consideration of all of the categories of disease that primarily or secondarily impair the functional integrity of the lymphatic system. Lymphedema is discussed, along with chromosomal disorders, lymphangioma, infectious diseases, lymphangioleiomyomatosis, lipedema, heritable genetic disorders, complex vascular malformations, protein‐losing enteropathy, and intestinal lymphangiectasia.