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The Role of dead‐end in Germ‐cell Tumor Development
Author(s) -
ZHU RUI,
BHATTACHARYA CHITRALEKHA,
MATIN ANGABIN
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1411.006
Subject(s) - germ cell , germ cell tumors , biology , germ , seminoma , embryonic stem cell , cell , cancer research , pathology , gene , genetics , microbiology and biotechnology , medicine , chemotherapy
: Testicular germ‐cell tumors occur in human males of all age groups, from infants to men over 50 years old. Most commonly, germ‐cell tumors (generally known as testicular cancer) occur in young males between the ages of 15 to 35 years. The tumor tissues are usually histologically diverse, and testicular tumors that occur in the different age groups tend to be of specific histological subtypes. Most germ‐cell tumors originate from primordial germ cells during embryonic development, although the progression and eventual detection of the disease occurs decades later in humans. Mouse strains spontaneously develop a specific subtype of testicular germ‐cell tumors, the type I germ‐cell tumors, and these tumors are similar to the germ‐cell tumors (or teratomas) that occur in human infants. Some mouse strains, such as the 129‐ Ter strain, have extremely high germ‐cell tumor incidences, making such strains ideal for genetic and biological studies of germ cell‐tumor development. Here a brief overview of the recently identified genetic defect in the Ter strain, inactivation of the dead‐end ( Dnd1 ) gene, and the ongoing studies on Dnd1 to understand its role in germ‐cell and germ cell‐tumor development, are provided.