Premium
Neonatal Programming of Rat Behavior by Downregulation of Alpha2A‐Adrenoreceptor Gene Expression in the Brain
Author(s) -
Dygalo Nikolay N.,
Kalinina Tatyana S.,
Shishkina Galina T.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1410.063
Subject(s) - neurochemical , downregulation and upregulation , gene knockdown , receptor , adrenergic receptor , gene expression , endocrinology , neuroscience , period (music) , medicine , gene , biology , microbiology and biotechnology , genetics , physics , acoustics
Short‐term knockdown of alpha2A‐adrenergic receptor gene expression in the rat brain by siRNA or antisense oligodeoxynucleotide during the first days of life induced acute and long‐lasting neurochemical and behavioral alterations. The acute effects in the neonatal rats were consistent with the known functions of the alpha2A‐adrenergic receptors in the mature animals. The long‐lasting alterations suggested involvement of receptor‐specific gene expression during the critical period of brain development in early‐life programming of anxiety‐related behavior.