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Degeneration of the Locus Ceruleus Noradrenergic Neurons in the Stress‐induced Depression of Rats
Author(s) -
Kitayama Isao T.,
Otani Masato,
Murase Sumio
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1410.059
Subject(s) - locus ceruleus , locus coeruleus , chemistry , endocrinology , medicine , stimulation , horseradish peroxidase , axon , tyrosine hydroxylase , intracellular , neuroscience , dopamine , biology , enzyme , substantia nigra , central nervous system , biochemistry , dopaminergic
We produced a model of depression in rats which have been exposed to 2‐weeks forced walking stress. Electron microscopic observation on the locus ceruleus (LC) cells of the model rats disclosed low dense areas, destroyed membranes, aggregation of intracellular organs, and increased microglia. Density of LC axon terminals in the frontal cortex stained with dopamine β‐hydroxylase antiserum and percentage of LC cells stained with horseradish peroxidase or activated by electrical stimulation antidromically were low in the model. These indices increased in the model treated with imipramine. These findings suggest that the LC noradrenergic neurons degenerate in depression, but regenerate in remission.