Premium
The Molecular and Cellular Aspects of Arthritis Due to Alphavirus Infections
Author(s) -
RULLI NESTOR E.,
MELTON JULIAN,
WILMES ANJA,
EWART GARY,
MAHALINGAM SURESH
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1408.007
Subject(s) - alphavirus , alphavirus infection , ross river virus , sindbis virus , chikungunya , virology , virus , togaviridae , arthritis , biology , arbovirus , outbreak , immunology , genetics , gene , rna
Alphaviruses such as the Sindbis‐group viruses, Scandinavian Ockelbo virus, the African Asian chikungunya virus, the African O'nyong‐nyong virus, the South American Mayaro virus, and the Australasian Barmah Forest and Ross River viruses, are commonly associated with outbreaks of acute and persistent arthritis and arthralgia in humans. The mechanisms by which these viruses cause arthritis/arthralgia are poorly understood. This chapter summarizes our current understanding of viral arthritides using our newly developed mouse model of Ross River virus‐induced joint and muscle inflammation.