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Avian and Human Metapneumovirus
Author(s) -
BROOR SHOBHA,
BHARAJ PREETI
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1408.005
Subject(s) - metapneumovirus , human metapneumovirus , pneumovirus , virology , paramyxoviridae , pneumovirinae , biology , virus , bronchiolitis , human pathogen , viral disease , respiratory tract infections , respiratory system , bacteria , genetics , anatomy
Pneumovirus infection remains a significant problem for both human and veterinary medicine. Both avian pneumovirus (aMPV, Turkey rhinotracheitis virus) and human metapneumovirus (hMPV) are pathogens of birds and humans, which are associated with respiratory tract infections. Based on their different genomic organization and low level of nucleotide (nt) and amino acid (aa) identity with paramyxoviruses in the genus Pneumovirus , aMPV and hMPV have been classified into a new genus referred to as Metapneumovirus . The advancement of our understanding of pneumovirus biology and pathogenesis of pneumovirus disease in specific natural hosts can provide us with strategies for vaccine formulations and combined antiviral and immunomodulatory therapies.