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Characteristics of the Protective Subcellular Coccidioidal T27K Vaccine
Author(s) -
JOHNSON SUZANNE M.,
KEREKES KATHLEEN M.,
LUNETTA JENNINE M.,
PAPPAGIANIS DEMOSTHENES
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1406.016
Subject(s) - adjuvant , thimerosal , antigen , alum , anthrax vaccines , respiratory system , chemistry , immunology , pharmacology , virology , medicine , immunization , dermatology , organic chemistry , dna vaccination
: While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal‐inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.