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Caspase‐3 and Bcl‐2 Expression in Aging in Adrenal Zona Reticularis After Dexamethasone Administration
Author(s) -
ALMEIDA HENRIQUE,
MATOS LILIANA,
NEVES DELMINDA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1404.021
Subject(s) - dexamethasone , zona reticularis , apoptosis , colocalization , medicine , endocrinology , caspase 3 , programmed cell death , biology , zona glomerulosa , microbiology and biotechnology , biochemistry , angiotensin ii , blood pressure
: Adrenocortical cell death by apoptosis is a common finding when adrenocorticotropic hormone is suppressed. Despite the well‐known final structural features exhibited by those cells, data on the mechanisms preceding these final events are lacking. In this study, after 3 days of dexamethasone administration to rats of different ages, rat adrenals were processed for immunocytochemical study. In the zona reticularis, there was evidence of the activation of Bcl‐2 and caspase‐3 proteins. Beyond a small age‐related increase in labeled cells, the number of cells presenting colocalization for both proteins was noteworthy. The results confirm the involvement of Bcl‐2 and caspase‐3 proteins in the apoptotic pathway and suggest their simultaneous intervention.