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Proresorptive Actions of FSH and Bone Loss
Author(s) -
ZAIDI MONE,
BLAIR HARRY C.,
IQBAL JAMEEL,
ZHU LING LING,
KUMAR T. RAJENDRA,
ZALLONE ALBERTA,
SUN LI
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1402.056
Subject(s) - endocrinology , bone resorption , medicine , estrogen , follicle stimulating hormone , resorption , hormone , osteoporosis , chemistry , luteinizing hormone
: We review studies that propose follicle‐stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor.