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Parathyroid Hormone Stimulation of Noncanonical Wnt Signaling in Bone
Author(s) -
BERGENSTOCK MARIKA K.,
PARTRIDGE NICOLA C.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1402.047
Subject(s) - wnt signaling pathway , anabolism , parathyroid hormone , catabolism , endocrinology , signal transduction , osteoporosis , medicine , stimulation , hormone , bone formation , lrp5 , osteoblast , chemistry , biology , microbiology and biotechnology , calcium , metabolism , biochemistry , in vitro
Abstract : In bone, parathyroid hormone (PTH) exerts either a catabolic or an anabolic effect depending on its method of administration. This paradoxical action has led to the use of PTH as an effective treatment for osteoporosis. The Wnt family of signaling proteins has a critical role in multiple events, which are necessary for proper animal development and survival, yet their exact method of action in bone remains elusive. We have uncovered a novel link between Wnt‐4 and PTH. We think that, in bone, Wnt‐4 signaling in response to PTH implicates cross‐talk of multiple signaling pathways. This work hopes to further elucidate Wnt signaling in bone and provide greater understanding of PTH's anabolic effects in bone.