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Differential Effects of Vascular Endothelial Growth Factor on Joint Formation during Limb Development
Author(s) -
CORTINARAMÍREZ GLORIA EMELÍ,
CHIMALMONROY JESÚS
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1402.024
Subject(s) - limb development , differential (mechanical device) , joint (building) , microbiology and biotechnology , biology , physics , engineering , structural engineering , embryo , thermodynamics
: During skeletal development the proliferating chondrocytes choose between two fates: to differentiate into prejoint cells or undergo hypertrophy. Vascular endothelial growth factor (VEGF) participates in endochondral ossification, but it is unknown whether it has a role in joint development. We evaluated the VEGF effects on joints, implanting VEGF‐beads in the presumptive limb joints of chick embryos. The wrist and elbow showed partial and complete fusions. Using the model of ectopic digits induced by transforming growth factor‐β (TGF‐β), VEGF inhibited joint formation when it was applied after TGF‐β. These data suggest differential effects of VEGF on different joints during development.