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TRAIL Is Involved in Human Osteoclast Apoptosis
Author(s) -
BRUNETTI GIACOMINA,
ORANGER ANGELA,
MORI GIORGIO,
TAMMA ROBERTO,
DI BENEDETTO ADRIANA,
PIGNATARO PAOLO,
GRASSI FELICE R.,
ZALLONE ALBERTA,
GRANO MARIA,
COLUCCI SILVIA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1402.011
Subject(s) - apoptosis , osteoclast , microbiology and biotechnology , chemistry , biology , genetics , in vitro
: Control of osteoclast (OC) apoptosis has been recognized as a critical regulatory factor in bone remodeling. TRAIL, a member of the TNF superfamily, induces apoptosis in neoplastic and normal cells. However, few data are available on the effects of TRAIL on bone cells, thus in the present study we investigated TRAIL role on the apoptosis of human mature OCs. We show that TRAIL treatment causes reduced cell viability, loss of nuclei integrity, and derangement of the actin microfilament in OCs. We also demonstrated that the death receptor DR5, upregulated by TRAIL, could be the mediator of TRAIL‐induced OC apoptosis.