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Negative Regulation of Otic Capsule Chondrogenesis
Author(s) -
LIU WEI,
BUTTS SYDNEY,
KIM HAROLD,
FRENZ DOROTHY A.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1402.005
Subject(s) - smad , chondrogenesis , endochondral ossification , microbiology and biotechnology , bone morphogenetic protein , chemistry , bone morphogenetic protein 2 , cartilage , otosclerosis , anatomy , signal transduction , medicine , endocrinology , biology , in vitro , biochemistry , surgery , gene
: The transforming growth factor‐beta (TGF‐β) superfamily, including TGF‐β1 and bone morphogenetic protein (BmP2, BmP4), participates in the regulation of the developing cartilaginous otic capsule, which prefigures the endochondral bony labyrinth of the inner ear. This study investigates Smad‐6 and ‐7, downstream components of the TGF‐β/BMP signaling pathway, in otic capsule chondrogenic control, and supports a function for these inhibitory Smads as negative regulators of capsule chondrogenesis. The importance of otic capsule chondrogenic control and implications of Smad signaling for otosclerosis, a disease affecting the endochondral bony labyrinth, are indicated.