Premium
Orbitofrontal Cortex and Cognitive‐Motivational Impairments in Psychostimulant Addiction
Author(s) -
OLAUSSON PETER,
JENTSCH J. DAVID,
KRUEGER DILJA D.,
TRONSON NATALIE C.,
NAIRN ANGUS C.,
TAYLOR JANE R.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1401.016
Subject(s) - orbitofrontal cortex , addiction , psychology , neuroscience , impulse control disorder , cognition , compulsive behavior , dysfunctional family , prefrontal cortex , medicine , clinical psychology , pathology , pathological
: Addiction is characterized by compulsive drug use despite adverse consequences. The precise psychobiological changes that underlie the progression from casual use to loss of control over drug‐seeking and drug‐taking behavior are not well understood. Here we report that short‐term cocaine exposure in monkeys is sufficient to produce both selective deficits in cognitive functions dependent on the orbitofrontal cortex (OFC) concurrent with enhancements in motivational processes involving limbic‐striatal regions. Additional findings from behavioral studies and analyses of the synaptic proteome provide new behavioral and biochemical evidence that cocaine‐induced neuroadaptations in cortical and subcortical brain regions result in dysfunctional decision‐making abilities and loss of impulse control that in combination with enhancements of incentive motivation may contribute to the development of compulsive behavior in addiction.