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Evaluation of Current Methods for the Measurement of Serum Anti–Double‐Stranded DNA Antibodies
Author(s) -
GHIRARDELLO ANNA,
VILLALTA DANILO,
MOROZZI GABRIELLA,
AFELTRA ANTONELLA,
GALEAZZI MAURO,
GERLI ROBERTO,
MATHIEU ALESSANDRO,
MERONI PIER LUIGI,
MIGLIORINI PAOLA,
RADICE ANTONELLA,
RICCIERI VALERIA,
RUFFATTI AMELIA,
SEBASTIANI GIAN DOMENICO,
TINCANI ANGELA,
DORIA ANDREA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1398.045
Subject(s) - antibody , dna , double stranded , current (fluid) , virology , computational biology , medicine , biology , immunology , genetics , physics , thermodynamics
: Autoantibodies to double‐stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti‐dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti‐dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.