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Effector Memory CD8 + T Cells Are Resistant to Apoptosis
Author(s) -
GUPTA SUDHIR,
GOLLAPUDI SASTRY
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1398.017
Subject(s) - effector , cytotoxic t cell , apoptosis , cd8 , microbiology and biotechnology , biology , immunology , chemistry , immune system , genetics , in vitro
: Based upon their migrating properties and effector functions, CD8 + T cells have been further classified into central memory (T CM ) and two types of effector memory (T EM and T EMRA ) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeostasis, we have examined the relative sensitivity of naïve (T N ) and different memory CD8 + T cells to apoptosis. We show that both T EM and T EMRA CD8 + T cells are resistant to apoptosis, whereas T N and T CM CD8 + T cells are sensitive to apoptosis.