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The Nature and Nurture of Common Autoimmunity
Author(s) -
CASTIBLANCO JOHN,
ANAYA JUANMANUEL
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1398.001
Subject(s) - nature versus nurture , autoimmunity , immunology , mechanism (biology) , trait , autoimmune disease , immune system , biology , medicine , genetics , antibody , philosophy , epistemology , computer science , programming language
: Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Although their heterogeneity is due to a collection of diverse conditions based on epidemiology, pathology, or diagnostic criteria, the underlying immunogenetic mechanism might be similar. Herein the nature and nurture of autoimmune diseases considered as a trait are reviewed, and a discussion is given on their multifactorial characteristics.