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The Role of Selenite on Microglial Migration
Author(s) -
PUPPA LISA DALLA,
SAVASKAN NICOLAI E.,
BRÄUER ANJA U.,
BEHNE DIETRICH,
KYRIAKOPOULOS ANTONIOS
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1397.084
Subject(s) - selenium , excitotoxicity , microglia , oxidative stress , microbiology and biotechnology , chemistry , programmed cell death , apoptosis , inflammation , biology , immunology , biochemistry , organic chemistry
: Oxidative brain damage, such as excitotoxicity and stroke, leads to primary neuronal destruction. The primary damage is further potentiated by macrophages and microglial cells, which are attracted and invade into the zone of damage resulting in secondary neuronal death. Since the essential trace element selenium has anti‐inflammatory properties, we analyzed the effects of selenium on these inflammatory cells. Here, we show that the essential trace element selenium abrogates the stress‐induced migration of microglial cells. Thus, the antimigratory effects of selenium may attenuate the secondary cell death cascade by preventing microglial invasion.