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Inhibitory Effects of 7‐Carboxymethyloxy‐3′,4′,5‐Trimethoxy Flavone (DA‐6034) on Helicobacter pylori ‐Induced NF‐κB Activation and iNOS Expression in AGS Cells
Author(s) -
LEE JEONGSANG,
KIM HYUNSOO,
HAHM KIBAIK,
SOHN MIWON,
YOO MOOHI,
JOHNSON JEFFREY A.,
SURH YOUNGJOON
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1397.057
Subject(s) - helicobacter pylori , inflammation , pathogenesis , gastritis , stomach , nf κb , cancer , chronic gastritis , immunology , medicine
: The Helicobacter pylori were identified by Marshall and Warren in 1984. H. pylori survive in the forbidding harsh acid environment of the stomach and duodenum by hiding in the mucus layer and neutralizing gastric acid in its local surrounding environment. Multiple lines of evidence suggest that H. pylori infection is one of the primary causes of gastritis and peptic ulcer, which are provoked by oxidative stress and inflammation. More than 50% of the world's population is infected by this bacterium. The H. pylori ‐induced inflammation has been implicated in the pathogenesis and progression of gastric cancer. DA‐6034 (7‐carboxymethyloxy‐3′,4′,5‐trimethoxy flavone) is a synthetic flavonoid known to possess anti‐inflammatory activity. It has been reported that oral administration of DA‐6034 suppresses the inflammatory bowel disease (IBD) in animal models. In this article, we attempted to examine the effect of DA‐6034 on H. pylori ‐induced inflammation in human gastric cancer (AGS) cells by targeting NF‐κB and extracellular signal‐regulated kinase (ERK), a representative MAPK.