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Intermittent Dietary Restriction as a Practical Intervention in Aging
Author(s) -
SHARMA SANDEEP,
KAUR GURCHARAN
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1396.031
Subject(s) - neural cell adhesion molecule , glial fibrillary acidic protein , oxidative stress , heat shock protein , endocrinology , neuroplasticity , antioxidant , biology , medicine , psychology , neuroscience , biochemistry , cell , cell adhesion , immunohistochemistry , gene
: Recent studies on the effects of dietary restriction (DR) in rodents and primates have shown that even late‐onset short‐term regimens can bring about comparable beneficial changes seen in animals subjected to life‐long DR. We examined the effect of 3 months of DR on the expression of antioxidant enzymes and antioxidants, heat‐shock protein 70 (HSP‐70), neural cell adhesion molecule (NCAM) and its polysialylated form, PSA‐NCAM, as well as astrocytic marker glial fibrillary acidic protein (GFAP) in 18‐month‐old middle‐aged rats. The present study shows that DR initiated in late adulthood confers beneficial effects, such as attenuation of oxidative stress, enhanced expression of HSP‐70, neural plasticity markers NCAM, and PSA‐NCAM, and reduced levels of GFAP.