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Psoralea corylifolia L. Inhibits Mitochondrial Complex I and Proteasome Activities in SH‐SY5Y Cells
Author(s) -
TANG SOON YEW,
GRUBER JAN,
WONG KIM PING,
HALLIWELL BARRY
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1395.053
Subject(s) - psoralea corylifolia , oxidative stress , traditional medicine , vitality , population , chemistry , pharmacology , biology , medicine , biochemistry , alternative medicine , genetics , environmental health , pathology
: The growing interest in alternative medicines, including traditional medicinal plants, has caused some health concerns due to poor awareness in the general population of the possible side effects from inappropriate practices. Psoralea corylifolia L. has been used in Chinese and Indian traditional medicine for the treatment of various inflammatory diseases of the skin and to improve vitality. Our data show that the extract obtained from the seeds of Psoralea corylifolia L. decreased mitochondrial complex I and proteasome activities; and oxidative stress might be an early event.