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CCR5 Receptor
Author(s) -
BALISTRERI CARMELA RITA,
CARUSO CALOGERO,
GRIMALDI MARIA PAOLA,
LISTÌ FLORINDA,
VASTO SONYA,
ORLANDO VALENTINA,
CAMPAGNA ANNA MARIA,
LIO DOMENICO,
CANDORE GIUSEPPINA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1395.014
Subject(s) - chemokine receptor , chemokine receptor ccr5 , ccr2 , chemokine , ccr1 , immunology , biology , receptor , effector , cc chemokine receptors , co receptor , macrophage , cancer research , inflammation , human immunodeficiency virus (hiv) , genetics , in vitro
: The CC chemokine receptor 5 (CCR5) is a member of CC‐chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein–coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co‐receptor for macrophage (M) and dual (T cell and M)‐tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age‐related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5Δ32 deletion and cardiovascular diseases and Alzheimer's disease.