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Human Clonal CD8 Autoreactivity to an IGRP Islet Epitope Shared between Mice and Men
Author(s) -
UNGER W.W.J.,
PINKSE G.G.M.,
MULDERvan der KRACHT S.,
Van Der SLIK A.R.,
KESTER M.G.D.,
OSSENDORP F.,
DRIJFHOUT J.W.,
SERREZE D.V.,
ROEP B.O.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1394.024
Subject(s) - epitope , islet , immunology , biology , antigen , endocrinology , diabetes mellitus
: Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin‐producing β cells by autoreactive T cells. CD8 + T cells play an essential role in this β cell destruction. However, little is known about the target antigens of CD8 + T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet‐specific glucose‐6‐phosphatase catalytic subunit–related protein (IGRP), IGRP 265‐273, which has recently been identified as a target in non‐obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8 + T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.