Refinement of the  Iddm4  Diabetes Susceptibility Locus Reveals  TCRVβ4  as a Candidate Gene | Zendy

BLANKENHORN ELIZABETH P. | Zendy; DESCIPIO CHERYL | Zendy; RODEMICH LUCY | Zendy; CORT LAURA | Zendy; LEIF JEAN H. | Zendy; GREINER DALE L. | Zendy; MORDES JOHN P. | Zendy

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Refinement of the Iddm4 Diabetes Susceptibility Locus Reveals TCRVβ4 as a Candidate Gene

Author(s) -

BLANKENHORN ELIZABETH P.,

DESCIPIO CHERYL,

RODEMICH LUCY,

CORT LAURA,

LEIF JEAN H.,

GREINER DALE L.,

MORDES JOHN P.

Publication year - 2007

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1394.020

Subject(s) - congenic , major histocompatibility complex , gene , diabetes mellitus , locus (genetics) , genetics , biology , candidate gene , endocrinology

: Iddm4 is a dominant non‐major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC‐identical normal WF rats, Iddm4 d sensitively and specifically predicts induced diabetes. We report a new diabetes‐susceptible subcongenic line that carries Iddm4 in a < 2.6 megabase interval. Candidate genes include the T cell receptor β chain variable ( TCRV β) family. We found that TCRV β 4 in WF rats contains a stop codon, whereas 5/5 diabetes‐susceptible rat strains express TCRV β 4 . We conclude that Iddm4 ‐mediated diabetes resistance in rats may be due to a recessive protective mutation in TCRV β 4 .

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