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Experimental Autoimmune Encephalomyelitis Mediated by CD8 + T Cells
Author(s) -
JI QINGYONG,
GOVERMAN JOAN
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1394.017
Subject(s) - experimental autoimmune encephalomyelitis , multiple sclerosis , immunology , cd8 , encephalomyelitis , immune system , t cell , cytotoxic t cell , autoimmune disease , myelin , pathogenesis , biology , central nervous system , neuroscience , antibody , genetics , in vitro
: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is believed to have an autoimmune origin. CD4 + T cells have been well studied for their involvement in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). CD8 + T cells, however, have been overlooked until recently, when more attention has focused on their potential role in pathogenic mechanisms in MS. Here we summarize our work in generating a CD8 + T cell–mediated EAE model. We discuss immune tolerance mechanisms that regulate CD8 + T cells specific for myelin basic protein (MBP), and describe initial results regarding triggers of CD8 + T cell–mediated disease. The availability of CD8 + T cell–mediated EAE models will help to elucidate the pathogenic roles of CD8 + T cells in MS, and provide tools for development of novel therapies for MS.