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Resistance to the Induction of Mixed Chimerism in Spontaneously Diabetic NOD Mice Depends on the CD40/CD154 Pathway and Donor MHC Disparity
Author(s) -
LUO BIN,
WU TAO,
PAN YISHENG,
SOZEN HAKAN,
HAO JIANQIANG,
ZHANG YU,
SUTHERLAND DAVID E. R.,
HERING BERNHARD J.,
GUO ZHIGUANG
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1394.015
Subject(s) - nod , cd154 , nod mice , cd40 , immunology , medicine , transplantation , major histocompatibility complex , diabetes mellitus , immune system , biology , endocrinology , cytotoxic t cell , in vitro , biochemistry
: Blockade of CD40/CD154 pathway has proven effective in promoting the induction of allogeneic mixed chimerism. Using NOD mouse model of human type 1 diabetes, we investigated whether allogeneic mixed chimerism can be induced in prediabetic NOD mice and in spontaneously diabetic NOD mice under nonmyeloablative and irradiation‐free conditioning therapy and anti‐CD154 mAb as a short‐term posttransplant treatment. We found that spontaneously diabetic NOD mice are more resistant to the induction of allogeneic mixed chimerism than prediabetic NOD mice under our nonmyeloablative and irradiation‐free conditioning therapy. This alloresistance in spontaneously diabetic NOD mice is dependent on the CD40/CD154 pathway and donor MHC disparity.