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Autoimmunity and β Cell Regeneration in Mouse and Human Type 1 Diabetes
Author(s) -
ABLAMUNITS VITALY,
SHERRY NICOLE A.,
KUSHNER JAKE A.,
HEROLD KEVAN C.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1394.006
Subject(s) - autoimmunity , regeneration (biology) , islet , type 1 diabetes , immunology , cell , immune system , autoimmune disease , cell type , diabetes mellitus , medicine , biology , microbiology and biotechnology , endocrinology , biochemistry , antibody
: Accumulating data from animal models of type 1 diabetes and some findings from clinical studies suggest that autoimmune destruction of islet β cells is associated with enhanced β cell regeneration. Successful immune therapies, aimed at preservation of islet cell mass, result in a remarkable reduction of β cell regeneration. Treated or not, as long as the task of treatment is limited by “making peace” with autoimmunity, the process of β cell loss continues. Additional therapeutic modalities capable of stimulating β cell regeneration in the absence of active autoimmune destruction are urgently needed.