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Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2
Author(s) -
De HAAN GERALD,
GERRITS ALICE
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1392.008
Subject(s) - ezh2 , epigenetics , stem cell , prc2 , haematopoiesis , biology , bmi1 , polycomb group proteins , histone , hematopoietic stem cell , microbiology and biotechnology , gene , genetics , gene expression , repressor
Hematopoietic stem cells have potent, but not unlimited, selfrenewal potential. The mechanisms that restrict selfrenewal are likely to play a role during aging. Recent data suggest that the regulation of histone modifications by Polycomb group genes may be of crucial relevance to balance selfrenewal and aging. We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system.