Premium
Gradients of Antigen Expression and Developmental Potential in Hematopoiesis
Author(s) -
KWAK JAEYONG,
CHO SCOTT,
SPANGRUDE GERALD J.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1392.002
Subject(s) - haematopoiesis , progenitor cell , antigen , biology , stem cell , microbiology and biotechnology , immunology , cellular differentiation , progenitor , genetics , gene
Prospective isolation of hematopoietic stem and progenitor cell subsets depends upon the premise that expression of combinations of surface antigens reflects developmental potential. During the process of differentiation, however, the loss of antigens associated with stem cells and the concomitant gain of those associated with progenitor cells often occurs as a continuum rather than by discrete binary steps. Coupled with the fact that assay conditions can profoundly influence the developmental fates of prospectively isolated cells, gradients of antigen expression during differentiation have led to a variety of interpretations of lineage commitment in hematopoiesis.