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Regulation of Na + /Ca 2+ Exchange Current in the Normal and Failing Heart
Author(s) -
REPPEL MICHAEL,
FLEISCHMANN BERND K.,
REUTER HANNES,
PILLEKAMP FRANK,
SCHUNKERT HERIBERT,
HESCHELER JÜRGEN
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1387.065
Subject(s) - regulator , kinase , function (biology) , chemistry , nucleotide , microbiology and biotechnology , biochemistry , biology , gene
Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na + and Ca 2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.