Regulation of Na + /Ca 2+  Exchange Current in the Normal and Failing Heart | Zendy

REPPEL MICHAEL | Zendy; FLEISCHMANN BERND K. | Zendy; REUTER HANNES | Zendy; PILLEKAMP FRANK | Zendy; SCHUNKERT HERIBERT | Zendy; HESCHELER JÜRGEN | Zendy

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Regulation of Na + /Ca 2+ Exchange Current in the Normal and Failing Heart

Author(s) -

REPPEL MICHAEL,

FLEISCHMANN BERND K.,

REUTER HANNES,

PILLEKAMP FRANK,

SCHUNKERT HERIBERT,

HESCHELER JÜRGEN

Publication year - 2007

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1387.065

Subject(s) - regulator , kinase , function (biology) , chemistry , nucleotide , microbiology and biotechnology , biochemistry , biology , gene

Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na + and Ca 2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.

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