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Three Types of Muscles Express Three Sodium–Calcium Exchanger Isoforms
Author(s) -
LEVITSKY DMITRI O.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1387.063
Subject(s) - sodium calcium exchanger , gene isoform , calcium , chemistry , sodium , microbiology and biotechnology , biophysics , biochemistry , biology , gene , organic chemistry
The sodium–calcium exchanger (NCX) of plasma membrane is expressed in any animal cell. The specific role of its three isoforms (NCX1–3) is not yet established. Their levels vary considerably during murine postnatal development. In particular, in skeletal muscle, NCX1 expression decreases gradually upon aging while reciprocal changes take place for NCX3. NCX2 expression is restricted to brain and smooth muscles. The data on SDS‐gel mobility shifts indicate that all three isoforms undergo Ca 2+ ‐dependent conformational changes, and that an exchanger regulatory Ca 2+ ‐binding domain interacts directly with mutually exclusive exons A and B inducing two different NCX1 conformations.