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Modulation Pathways of NCX mRNA Stability
Author(s) -
MAEDA SACHIKO,
MATSUOKA ISAO,
KIMURA JUNKO
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1387.062
Subject(s) - rhob , lysophosphatidylcholine , messenger rna , chemistry , microbiology and biotechnology , signal transduction , biology , biochemistry , gene , phospholipid , rhoa , membrane , phosphatidylcholine
Cardiac Na + /Ca 2+ exchanger 1 (NCX1) expression levels change under various pathophysiological conditions. However, its mechanism is unknown. We found that fluvastatin, an HMG‐CoA reductase inhibitor, decreased NCX1 mRNA and protein by inhibiting a small G protein, RhoB, in H9c2 cardiomyoblasts. Conversely, lysophosphatidylcholine (LPC) increased NCX1 mRNA and protein by activating RhoB. The effect of LPC was mediated by geranylgeranylation but not farnesylation of RhoB. Furthermore, we also detected that activation of RhoB increased NCX1 mRNA stability. Our results suggest that RhoB is involved in modulation of cardiac NCX1 mRNA expression.