Examining Ca 2+  Extrusion of Na + /Ca 2+ ‐K +  Exchangers | Zendy

ALTIMIMI HAIDER F. | Zendy; SCHNETKAMP PAUL P. M. | Zendy

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Examining Ca 2+ Extrusion of Na + /Ca 2+ ‐K + Exchangers

Author(s) -

ALTIMIMI HAIDER F.,

SCHNETKAMP PAUL P. M.

Publication year - 2007

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1387.056

Subject(s) - chemistry , extrusion , intracellular , ion exchange , ionic bonding , ion transporter , analytical chemistry (journal) , ion , membrane , biophysics , inorganic chemistry , chromatography , biochemistry , materials science , organic chemistry , biology , metallurgy

Na + /Ca 2+ ‐K + exchangers (NCKX) are plasma membrane transporters that are thought to mainly mediate Ca 2+ extrusion (along with K + ) at the expense of the Na + electrochemical gradient. However, because they are bidirectional, most assays have relied on measuring their activity in the reverse (Ca 2+ import) mode. Herein we describe a method to control intracellular ionic conditions, and examine the forward (Ca 2+ extrusion) mode of exchange of NCKX2.

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