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Role of Plasma Membrane Calcium ATPase Isoform 2 in Neuronal Function in the Cerebellum and Spinal Cord
Author(s) -
KURNELLAS MICHAEL P.,
LEE AMANDA K.,
SZCZEPANOWSKI KAROLYNN,
ELKABES STELLA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1387.025
Subject(s) - spinal cord , cerebellum , gene isoform , plasma membrane ca2+ atpase , neuroscience , central nervous system , calcium , biology , nervous system , atpase , microbiology and biotechnology , medicine , enzyme , gene , biochemistry
The distinct role of plasma membrane calcium ATPase 2 (PMCA2) in the function of different neuronal subpopulations in the central nervous system is not well understood. We found that lack of PMCA2 leads to a reduction in the number of motor neurons in the spinal cord of PMCA2‐null mice and to abnormal changes in molecular pathways in Purkinje cells. Thus, PMCA2 may have unique, nonredundant functions in spinal cord and cerebellar neurons. Our results suggest that anomalous alterations in PMCA2 activity or expression may induce pathology in some neuronal populations, a possibility that will be the focus of future investigations.