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Immunoassay‐Based Diagnostic Point‐of‐Care Technology for Oral Specimen
Author(s) -
MUNJAL SARVAN,
MIETHE PETER,
NETUSCHIL LUTZ,
STRUCK FRIEDHELM,
MAIER KURT,
BAUERMEISTER CLAUS
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1384.017
Subject(s) - immunoassay , saliva , point of care , horseradish peroxidase , point of care testing , streptococcus sobrinus , dentistry , medicine , streptococcus mutans , chemistry , antibody , immunology , pathology , biology , bacteria , biochemistry , genetics , enzyme
: We have outlined our progress in developing a novel point‐of‐care platform to quantify micro‐organisms causing dental infections and/or inflammatory markers reflecting an oral disease status. This system is based on a sandwich immunoassay technology known as ABICAP (Antibody Immuno Column for Analytical Processes) using poly‐horseradish peroxidase conjugates. This assay enabled us to quantify 500 colony‐forming units of Streptococcus sobrinus per milliliter of saliva. The platform allows rapid and convenient performance chairside of such tests by a dentist or dental hygienist within 20 minutes at the dental office.