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Increased Angiogenesis at the Site of Abdominal Aortic Aneurysm Rupture
Author(s) -
CHOKE EDWARD,
COCKERILL GILLIAN W.,
DAWSON JOSEPH,
WILSON RICHARD W.,
JONES ALUN,
LOFTUS IAN M.,
THOMPSON MATTHEW M.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1383.007
Subject(s) - abdominal aortic aneurysm , matrix metalloproteinase , neovascularization , angiogenesis , aneurysm , medicine , extracellular matrix , aortic aneurysm , surgery , microbiology and biotechnology , biology
Abdominal aortic aneurysm (AAA) rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic aneurysm rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the aneurysm rupture edge compared with paired aneurysm anterior sac. Further investigations into the role of angiogenesis in aneurysm rupture may open novel therapeutic avenues to prevent aneurysm rupture.