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Structural and Functional Genetic Disorders of the Great Vessels and Outflow Tracts
Author(s) -
BEE KATHARINE J.,
WILKES DAVID,
DEVEREUX RICHARD B.,
LERMAN BRUCE B.,
DIETZ HARRY C.,
BASSON CRAIG T.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1383.002
Subject(s) - outflow , medicine , biology , geology , oceanography
Development of the aorta and pulmonary artery is a complex process involving multiple molecular genetic pathways that modulate morphogenesis of the outflow tracts and the anastomosis of branch vessels. Recent genetic studies of the cardiovascular system demonstrate that congenital and adult onset progressive disorders of the great vessels such as aneurysms are components of generalized vascular, cardiac, and extracardiovascular syndromes. Current paradigms suggest that aortic disease is founded in patterning anomalies of the conotruncus that occur in utero . These aberrations can be consequences of genetic aberrations in transcriptional regulation of signal transduction both within and outside the developing great vessels.