Premium
Role of the HLA Class II
Author(s) -
DE RE VALLI,
CAGGIARI LAURA,
SIMULA MARIA PAOLA,
DE VITA SALVATORE,
MAZZARO CESARE,
LENZI MARCO,
MASSIMO GALLI M.,
MONTI GIUSEPPE,
FERRI CLODOVEO,
ZIGNEGO ANNA LINDA,
GABRIELLI ARMANDO,
SANSONNO DOMENICO,
DAMMACCO FRANCO,
LIBRA MASSIMO,
SACCHI NICOLETTA,
TALAMINI RENATO,
SPINA MICHELE,
TIRELLI UMBERTO,
CANNIZZARO RENATO,
DOLCETTI RICCARDO
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1381.033
Subject(s) - human leukocyte antigen , class (philosophy) , immunology , computational biology , medicine , biology , computer science , antigen , artificial intelligence
The paper highlights the role of different HLA class II molecules in hepatic and lymphoproliferative HCV‐related disorders. HLA molecules have been reviewed, according to an in silico cluster classification, based on the sequence, the biochemical structure of the pockets, and the functional characteristics of the HLA II molecules. Thus, by reducing the complexity of HLA II polymorphism, charateristics that unite different HLA molecules with specific HCV‐associated pathologies may be recognized with greater case. Results show that HLA clusters associated with better dlimination of the virus are protective against HCC development, while the same clusters are associated with a higher risk of developing cryoglobulinemic syndrome and the concomitant NHL. These data added further acknowledgements on pathogenetic mechanisms associated with HCV infection. Results also highlight differences of NHL occurring in HCV‐positive subjects, with or without a concomitant type II autoimmune cryoglobulinemic syndrome, suggesting that cryoglobulinemic background associated with NHL should be considered in the evaluation of the effectiveness of new therapies in the course of HCV‐associated NHLs.