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Are Neurotrophins Important in Ulcerative Colitis?
Author(s) -
JOHANSSON MALIN,
NORRGÅRD ÖRJAN,
FORSGREN STURE
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1381.031
Subject(s) - neurotrophin , downregulation and upregulation , ulcerative colitis , glial cell line derived neurotrophic factor , nerve growth factor , neurotrophin 3 , lamina propria , medicine , low affinity nerve growth factor receptor , neurotrophic factors , disease , pathology , biology , brain derived neurotrophic factor , receptor , biochemistry , gene , epithelium
Neurotrophins are known to have growth, survival‐promoting, and healing effects. The importance of neurotrophins in ulcerative colitis (UC) is, however, unclear. Recent studies in our group revealed that an occurrence of marked changes in neurotrophin expression patterns was related to a worsening of the disease process. There was thus an upregulation for the lamina propria cells but a downregulation in nerve structures concerning neurotrophin expressions in severe UC. The observations show that changes in the neurotrophin system are a part of the disease process in UC and are of interest as treatments interfering with neurotrophin effects in other situations have been found to have trophic and healing effects.