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Cardiac Defibrillation and the Role of Mechanoelectric Feedback in Postshock Arrhythmogenesis
Author(s) -
GUREV VIATCHESLAV,
MALECKAR MARY M.,
TRAYANOVA NATALIA A.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1380.024
Subject(s) - mechanosensitive channels , defibrillation , cardiology , electric shock , biomedical engineering , medicine , materials science , chemistry , biophysics , ion channel , biology , electrical engineering , engineering , receptor
Ventricular dilatation increases the defibrillation threshold (DFT). In order to elucidate the mechanisms responsible for this increase, the present article investigates changes in the postshock behavior of the myocardium upon stretch. A two‐dimensional electro‐mechanical model of cardiac tissue incorporating heterogeneous fiber orientation was used to explore the effect of sustained stretch on postshock behavior via ( a ) recruitment of mechanosensitive channels (MSC) and ( b ) tissue deformation and concomitant changes in tissue conductivities. Recruitment of MSC had no influence on vulnerability to electric shocks as compared to control, but increased the complexity of postshock VF patterns. Stretch‐induced deformation and changes in tissue conductivities resulted in a decrease in vulnerability to electric shocks.