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Age‐Related Changes in Neuronal Susceptibility to Damage
Author(s) -
WANG AI LING,
YUAN MING,
NEUFELD ARTHUR H.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1379.027
Subject(s) - crush injury , optic nerve , ganglion , retinal ganglion cell , retinal , in vivo , biology , anatomy , medicine , ophthalmology , surgery , microbiology and biotechnology
To investigate whether or not the aging phenotype has increased vulnerability to axonal injury in vivo , we quantitated the loss of retinal ganglion cells (RGCs) after optic nerve crush. After crush, young animals lost 20% in 3 days and 50% of their RGCs in 7 days; however, old animals lost 40% in 3 days and 70% of their RGCs in 7 days. Our results showed that the time course in the loss of RGCs after crush in old mice is faster than that in young mice. Thus, old age increases susceptibility for the loss of RGCs following axonal damage.