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Fibrillar and Oligomeric β‐Amyloid as Distinct Local Biomarkers for Alzheimer's Disease
Author(s) -
MONTALTO MICHAEL C.,
FARRAR GILL,
HEHIR CRISTINA TAN
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1379.023
Subject(s) - amyloid (mycology) , disease , biomarker , amyloid β , neuroscience , β amyloid , medicine , alzheimer's disease , pathology , psychology , chemistry , biochemistry
β‐amyloid is a key component of Alzheimer's disease (AD) pathology. Researchers in both academic and industry are actively pursuing the development of imaging tracers and techniques to noninvasively measure local levels of β‐amyloid in the Alzheimer's brain. This presentation summarizes recent data and discusses the opportunities and challenges of imaging plaques containing fibrillar β‐amyloid for the early diagnosis and therapeutic monitoring of amyloid targeted therapies. Further, the value and feasibility of measuring the recently described soluble oligomeric form of β‐amyloid as an alternative noninvasive biomarker is also discussed.