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Biosignals Modulated by Tumor‐Associated Carbohydrate Antigens
Author(s) -
FURUKAWA KOICHI,
HAMAMURA KAZUNORI,
AIXINJUELUO WEI,
FURUKAWA KEIKO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1377.017
Subject(s) - ganglioside , paxillin , cancer research , monoclonal antibody , antigen , chemistry , melanoma , glycosyltransferase , cancer cell , cancer , microbiology and biotechnology , biochemistry , phosphorylation , biology , antibody , focal adhesion , immunology , gene , genetics
Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor‐associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC) were reported. GD3 enhances tyrosine phosphorylation of two adaptor molecules, p130Cas and paxillin, resulting in the increased cell growth and invasion in melanoma cells. GD2 also enhances the proliferation and invasion of SCLC cells. GD2 also mediates apoptosis with anti‐GD2 monoclonal antibodies (mAbs) via dephosphorylation of the focal adhesion kinase. These approaches have promoted further understanding of mechanisms by which gangliosides modulate malignant properties of human cancer, and the results obtained here propose novel targets for cancer therapy.