Premium
Involvement of DPPIV/CD26 in Epithelial Morphology and Suppressed Invasive Ability in Ovarian Carcinoma Cells
Author(s) -
KAJIYAMA HIROAKI,
SHIBATA KIYOSUMI,
TERAUCHI MIKIO,
INO KAZUHIKO,
NAWA AKIHIRO,
KIKKAWA FUMITAKA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1377.007
Subject(s) - dipeptidyl peptidase 4 , dipeptidyl peptidase , vimentin , ovarian carcinoma , mesenchymal stem cell , cancer research , biology , aminopeptidase , carcinoma , ovarian cancer , pathology , microbiology and biotechnology , medicine , immunohistochemistry , endocrinology , immunology , cancer , enzyme , biochemistry , diabetes mellitus , leucine , amino acid , type 2 diabetes
Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP‐2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP‐2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.