Involvement of DPPIV/CD26 in Epithelial Morphology and Suppressed Invasive Ability in Ovarian Carcinoma Cells | Zendy

KAJIYAMA HIROAKI | Zendy; SHIBATA KIYOSUMI | Zendy; TERAUCHI MIKIO | Zendy; INO KAZUHIKO | Zendy; NAWA AKIHIRO | Zendy; KIKKAWA FUMITAKA | Zendy

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Involvement of DPPIV/CD26 in Epithelial Morphology and Suppressed Invasive Ability in Ovarian Carcinoma Cells

Author(s) -

KAJIYAMA HIROAKI,

SHIBATA KIYOSUMI,

TERAUCHI MIKIO,

INO KAZUHIKO,

NAWA AKIHIRO,

KIKKAWA FUMITAKA

Publication year - 2006

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1377.007

Subject(s) - dipeptidyl peptidase 4 , dipeptidyl peptidase , vimentin , ovarian carcinoma , mesenchymal stem cell , cancer research , biology , aminopeptidase , carcinoma , ovarian cancer , pathology , microbiology and biotechnology , medicine , immunohistochemistry , endocrinology , immunology , cancer , enzyme , biochemistry , diabetes mellitus , leucine , amino acid , type 2 diabetes

Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP‐2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP‐2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.

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