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SFK–STAT Pathway: An Alternative and Important Way to Malignancies
Author(s) -
HAYAKAWA FUMIHIKO,
NAOE TOMOKI
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1377.002
Subject(s) - stat , stat5 , lyn , jak stat signaling pathway , stat protein , stat4 , microbiology and biotechnology , cancer research , signal transduction , phosphorylation , janus kinase , cytokine receptor , src family kinase , kinase , proto oncogene tyrosine protein kinase src , biology , stat3 , receptor tyrosine kinase
Signal transducers and activators of transcription (STAT) proteins play a crucial role in mediating signals from a diverse spectrum of cytokine receptors. STAT is thought to be activated by JAK family kinases (JFK) in many cytokine receptor signal pathways; however, recent studies have demonstrated an alternative pathway to activate STAT by Src family kinases (SFK) in growth factor receptor signal. We also observed STAT5 phosphorylation by Lyn, a member of SFK, in our two recent studies. We introduce these studies and review the literature of STAT activation by SFK and aberrant activation of STAT by oncogenic signals.