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TEDDY–The Environmental Determinants of Diabetes in the Young
Author(s) -
HAGOPIAN WILLIAM A.,
LERNMARK ÅKE,
REWERS MARIAN J.,
SIMELL OLLI G.,
SHE JINXIONG,
ZIEGLER ANETTE G.,
KRISCHER JEFFREY P.,
AKOLKAR BEENA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1375.049
Subject(s) - type 1 diabetes , psychosocial , medicine , diabetes mellitus , autoantibody , population , autoimmunity , genotype , human leukocyte antigen , islet , pediatrics , immunology , endocrinology , environmental health , disease , biology , antibody , psychiatry , antigen , genetics , gene
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: ( a ) appearance of islet autoantibodies and ( b ) clinical diagnosis of T1DM. Six clinical centers screen newborns for high‐risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High‐risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first‐degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.