TEDDY–The Environmental Determinants of Diabetes in the Young | Zendy

HAGOPIAN WILLIAM A. | Zendy; LERNMARK ÅKE | Zendy; REWERS MARIAN J. | Zendy; SIMELL OLLI G. | Zendy; SHE JINXIONG | Zendy; ZIEGLER ANETTE G. | Zendy; KRISCHER JEFFREY P. | Zendy; AKOLKAR BEENA | Zendy

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TEDDY–The Environmental Determinants of Diabetes in the Young

Author(s) -

HAGOPIAN WILLIAM A.,

LERNMARK ÅKE,

REWERS MARIAN J.,

SIMELL OLLI G.,

SHE JINXIONG,

ZIEGLER ANETTE G.,

KRISCHER JEFFREY P.,

AKOLKAR BEENA

Publication year - 2006

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1375.049

Subject(s) - type 1 diabetes , psychosocial , medicine , diabetes mellitus , autoantibody , population , autoimmunity , genotype , human leukocyte antigen , islet , pediatrics , immunology , endocrinology , environmental health , disease , biology , antibody , psychiatry , antigen , genetics , gene

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: ( a ) appearance of islet autoantibodies and ( b ) clinical diagnosis of T1DM. Six clinical centers screen newborns for high‐risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High‐risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first‐degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

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